Figure 15.

Proposed model of Selanotrastuzamab action. The promiscuity of epidermal growth factor receptor (EGFR) family binding and interaction may be one possible explanation for the observed cytotoxicity in the triple negative breast cancer cells. It is possible for Selanotrastuzamab to interact with other family members, allowing for endocytosis of a critical amount of selenium-bound trastuzumab. The selenium might then become liberated within the cytosol and enter the mitochondria where it disrupts cancer cell metabolism and produces reactive oxygen specieis (ROS).