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. 2018 Oct 26;19(11):3355. doi: 10.3390/ijms19113355

Table 5.

Interaction of common drugs used to treat GWI symptoms with AR agonist form. Mean binding energy and standard deviation are in units of kcal/mol. A t-test was used to compare to the known binder testosterone. (+) indicates putative binding, (−) indicates no putative binding, (*) indicates more in-depth analysis required.

Drug Mean StDev p-Value Interaction
Testosterone −9.61 0.55 1.00 +
Tetrahydrogestrinone −9.39 2.27 0.854 +
Ketorolac −8.67 0.26 0.0110 −
Paroxetine −8.37 0.41 0.0110 −
Trazodone −8.13 2.44 0.278 +
EM5744 −8.07 4.44 0.516 +
Sertraline −7.93 0.56 5.29 × 10−3 −
Carbamazepine −7.82 1.14 0.0244 +
Modafinil −7.74 0.56 1.55 × 10−3 −
Naproxen −7.73 0.47 8.81 × 10−4 −
Diclofenac −7.60 0.57 1.11 × 10−3 −
Fluvoxamine −7.60 1.15 1.92 × 10−2 −
Pindolol −7.30 0.47 2.45 × 10−4 −
Fludrocortisone −7.21 0.14 7.96 × 10−4 −
Cyclobenzaprine −7.17 0.54 2.74 × 10−4 −
Bupropion −7.16 0.28 9.55 × 10−4 −
Clonazepam −7.15 0.54 2.01 × 10−3 −
Fluoxetine −7.07 0.62 3.69 × 10−4 −
Nortriptyline −6.95 0.21 1.02 × 10−4 −
Citalopram −6.88 1.14 4.99 × 10−3 −
Doxepin −6.87 0.85 8.82 × 10−4 −
l-Tryptophan −6.83 0.55 1.35 × 10−4 −
Rofecoxib −6.80 1.47 0.0155 −
Baclofen −6.79 0.20 1.32 × 10−5 −
Ibuprofen −6.78 0.56 1.26 × 10−4 −
Methylphenidate −6.74 0.47 6.25 × 10−5 −
Amitriptyline −6.70 0.65 1.93 × 10−4 −
Atenolol −6.69 0.49 2.10 × 10−4 −
Venlafaxine −6.41 0.19 2.22 × 10−4 −
Gabapentin −6.38 0.37 1.50 × 10−5 −
Midodrine −6.30 0.95 4.71 × 10−4 −
Clofibrate −6.29 0.64 7.81 × 10−5 −
Oxazepam −6.11 2.05 0.0133 −
Buspirone −6.04 2.31 0.0203 +
Lorazepam −6.04 1.98 0.0106 −
Valaciclovir −5.88 0.86 1.40 × 10−4 −
Meclizine −5.87 0.73 5.60 × 10−4 −
Amantadine −5.73 1.33 9.83 × 10−4 −
Acetaminophen −5.47 0.66 2.16 × 10−5 −
Nefazodone −5.28 1.80 2.50 × 10−3 −
Dextroamphetamine −5.13 1.80 2.09 × 10−3 −
Diazepam −5.07 0.17 4.02 × 10−5 −
Alprazolam −4.78 1.27 2.04 × 10−4 −
Zopiclone −4.77 3.00 0.0162 −
Nimodipine −3.42 2.82 5.02 × 10−3 −
Celecoxib 6.95 2.73 2.14 × 10−5 −
Mifepristone 88.45 69.80 0.0335 *
Suramin 1171.30 899.94 0.0419 *