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. 2018 Nov 1;19(11):3431. doi: 10.3390/ijms19113431

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Neither lysosomal activity nor proteasomal activity is involved in downregulation of Bim_EL induced by melatonin. (A) Lysosomal inhibitor chloroquine (CQ) and Bafilomycin A1 (BA1) did not block the downregulation of Bim_EL caused by melatonin in porcine adherent granulosa cells. (B) Proteasomal inhibitor MG132 did not affect the downregulation of Bim_EL in porcine adherent granulosa cells. (C) Melatonin did not affect proteasomal activity. Values are expressed as the means ± S.D. of three separate experiments. * p < 0.05.