Figure 3.

p8^I inhibits T cell receptor (TCR) signal transduction and NFAT activation: p8^I is a proteolytic product of p12^I in the ER membranes, the protein traffics to plasma membrane and localizes in the immunological synapse; p8^I interacts with and inhibits the phosphorylation of the transmembrane protein called linker for activation of T cells (LAT) and by doing so, p8^I disables LAT to transmit signals from TCR and to interact with other proteins, such as phospholipase C gamma 1, Vav proteins, and lymphocyte-specific protein tyrosine kinase (shown in red, cyan and green) on the TCR signaling pathway.