Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 26;19(11):3333. doi: 10.3390/ijms19113333

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

A schematic for the mechanisms by which chemotherapy elicits its pro-cancer effect via modulations of macrophages and endothelial cells. Blue text indicates the changes induced by chemotherapy; blue arrow denotes increase induced by chemotherapy; black arrow indicates promoting the events; black down arrow indicates decrease. Mϕ, macrophage; TEM, Tie2-expressing macrophage; TMEM, tumor microenvironment metastasis; EC, endothelial cells; iM, inflammatory monocyte; DCs, dendritic cells; CTC, circulating cancer cells; TIC, tumor initiation cell; TIMP, tissue inhibitor of metallopeptidase; the green and pink shades denote that the corresponding cells are altered.