Figure 3.

A schematic for the “dysregulated adaptive-response hypothesis.” Briefly, dysregulation of cellular adaptive-response network plays a central role for seemingly different stressors, such as chemotherapy, tissue injuries, and tumor signals to enhance cancer progression and metastasis. The “wound healing program” denotes a generic program entailing the indicated processes (in bullet points). However, detailed molecules or genes involved may vary in different context. ECM, extracellular matrix; BM, bone marrow.