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Synthetic route of H2S-donating derivatives (121–125) of evodiamine. Reagents and conditions: (a) Br(CH2)nBr, potassium carbonate, reflux, 8 h; (b) Br(CH2)nCOOC2H5, NaH, 80 °C, 12 h; (c) potassium hydroxide, rt, 2 h; (d) α-thioctic acid, 117, EDCI, DMAP, rt, 8–12 h; (e) 118a–c, TEA, 80 °C, 8 h.
