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Diagrammatic illustration showing plausible mode of action of GA and BA in modulation of Sp1 and its targeted gene Prdx6 and in determining LECs fate. Oxidative stress-evoked aberrant Sumoylation signaling causing dysregulation of Sp1 activity and Prdx6 in LECs can be blunted by GA application. GA enhances Sp1 transcriptional activity by enhancing its cellular stability through inhibiting its aberrant Sumoylation.
