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VPA reduces FoxO1 recruitment at target genes in type 2 diabetic rats. Recruitment of FoxO1 and polymerase II to G6p (A); Fbp (B); Pck1 (C); or Pc (D) was higher in OLETF rats than that in LETO rats, an effect that was reduced by VPA administration for 20 weeks. The graphs show the mean ± SEM of six independent experiments (* p < 0.05 vs. vehicle LETO; # p < 0.05 vs. vehicle OLETF).
