Figure 4.

Epidermal ultrastructure of (a,c) non-glycated and (b,d) glycated RHS. (a) Lipid lamellae within the intercellular space of neighboring corneocytes. (b) Fine lines of the intercellular lipids are clearly visible (arrows). (c) Packed keratohyalin granule-like structures (arrows) in the upper layers of the viable epidermis, indicating the stratum granulosum. (d) The stratum granulosum dominates the epidermal compartment. Fine electron dense material evenly disseminated within the cytoplasm of the keratinocytes (arrows). Pictures are representative for two batches. (a,b). TEM, bar = 0.25 µm; (c,d) TEM, bar = 2.5 µm.