Table 1.
Estimated change (diff) in mean transformed apoptosis rate and DNA strand breaks. Effects listed below are described in Table 7.
| Effect | Diff | p Value |
|---|---|---|
| Apoptosis 0.8 Gy | ||
| R (1g) | 0.13 | 0.0000138 # |
| µg | −0.1 | 0.0156 |
| Iso × g | −0.1 | 0.0202 |
| R (µg) | 0.13 | 0.0498 |
| Iso (1g) | 0.06 | 0.103 |
| Iso (µg) | −0.05 | 0.149 |
| Iso × R × g | 0.06 | 0.278 |
| Iso (1g, R) | 0.04 | 0.313 |
| Iso × R (µg) | 0.04 | 0.34 |
| Iso × R (1g) | −0.02 | 0.684 |
| Iso (µg, R) | −0.01 | 0.724 |
| R × g | 0 | 0.941 |
| Apoptosis 2 Gy | ||
| R (µg) | 0.37 | 5.32 × 10−15 # |
| R (1g) | 0.39 | 0.0000189 # |
| Iso × R (1g) | −0.2 | 0.0000635 # |
| Iso (1g) | 0.11 | 0.000782 # |
| Iso × g | −0.12 | 0.00092 # |
| Iso (1g, R) | −0.09 | 0.00276 # |
| Iso (µg, R) | −0.06 | 0.00955 |
| Iso × R × g | 0.15 | 0.0148 |
| µg | −0.07 | 0.0156 |
| Iso × R (µg) | −0.05 | 0.123 |
| Iso (µg) | −0.01 | 0.218 |
| R × g | −0.02 | 0.612 |
| DNA strand breaks 2 Gy | ||
| µg | 0.78 | 0.000 # |
| Iso (1g, R) | 0.50 | 0.000 # |
| Iso (µg) | −0.60 | 0.000 # |
| Iso × R (µg) | −0.37 | 0.007 # |
| R (1g) | 0.35 | 0.010 # |
| R (µg) | 0.30 | 0.024 |
| Iso (1g) | −0.18 | 0.167 |
| Iso × R (1g) | 0.15 | 0.259 |
| Iso (µg, R) | −0.07 | 0.607 |
With control of the FWER (family-wise error rate—see statistical methods) to 5% (Holm) significant changes are highlighted with #. For apoptosis rate: n = 15 independent experiments for 0.8, n = 16 independent experiments for 2 Gy. p-value threshold: 0.0045 for 0.8 Gy and 0.0083 for 2 Gy. For DNA strand breaks: n = 6 independent experiments for 2 Gy. p-value threshold: 0.0125.