Table 3.
Significant differences in mean transformed gene expression (2 Gy). Effects listed below are described in Table 7.
| Gene | Effect | Diff | Se | Df | p Value |
|---|---|---|---|---|---|
| ADRB2 | R × g | −0.3369 | 0.0992 | 34.4 | 0.00174 |
| ADRB2 | R (µg) | 0.481 | 0.0848 | 34.4 | 2.20 × 10−6 |
| ADRB2 | Iso (1g) | 0.5047 | 0.1009 | 33.7 | 0.0000175 |
| ADRB2 | Iso (µg, R) | 0.5138 | 0.1528 | 19.1 | 0.00324 |
| ADRB2 | Iso × R × g | 0.6219 | 0.2297 | 48.1 | 0.00935 |
| ADRB2 | R (1g) | 0.8179 | 0.1239 | 19.2 | 2.42 × 10−6 |
| AKT1 | R (1g) | −0.2202 | 0.0598 | 18.9 | 0.00158 |
| AKT1 | R (µg) | −0.1696 | 0.0509 | 29.3 | 0.00234 |
| APEX1 | R (µg) | −0.4306 | 0.054 | 52.7 | 1.27 × 10−10 |
| BAX | R (1g) | 1.9229 | 0.102 | 5.96 | 1.54 × 10−6 |
| BAX | R (µg) | 1.9254 | 0.0481 | 28.2 | 1.97 × 10−26 |
| CASP3 | Iso (µg, R) | −0.4001 | 0.0794 | 55.4 | 5.38 × 10−6 |
| MDM2 | R (µg) | 1.6218 | 0.0694 | 9.65 | 8.14 × 10−10 |
| MDM2 | R (1g) | 1.6469 | 0.1196 | 7.75 | 1.00 × 10−6 |
| PARP1 | R (µg) | −0.3947 | 0.0465 | 32.5 | 9.41 × 10−10 |
| PARP1 | R (1g) | −0.2701 | 0.0602 | 20.8 | 0.000208 |
| PCNA | R (1g) | 1.2425 | 0.0831 | 13.2 | 1.19 × 10−9 |
| PCNA | R (µg) | 1.3845 | 0.046 | 80 | 0 |
| TP53 | R (µg) | −0.6312 | 0.056 | 47.6 | 5.04 × 10−15 |
| TP53 | R (1g) | −0.4132 | 0.0749 | 25.7 | 8.95 × 10−6 |
| XRCC5 | Iso (µg, R) | −0.2727 | 0.0225 | 146 | 7.45 × 10−24 |
| XRCC5 | Iso × R (µg) | −0.2678 | 0.0538 | 30.4 | 0.000024 |
Controlling the false-discovery rate (FDR) to 5% corresponded to a p-value threshold of 0.0098, which in turn led to the identification of 22 significant contrasts among the 180 that were estimated. n = 10 independent experiments. Iso = isoproterenol, R = 2 Gy radiation, g = gravity. p-value threshold p < 0.0098 after controlling the FDR to 5%. Diff = estimated difference, se = standard error, df = degrees of freedom.