Table 5.
Significant differences in mean transformed cytokine concentration (2 Gy). Effects listed below are described in Table 7.
| Cyt | Effect | Diff | Se | Df | p Value |
|---|---|---|---|---|---|
| GM-CSF | Iso (µg, R) | −4.4 | 0.5784 | 31.2 | 1.36 × 10−8 |
| GM-CSF | Iso (1g) | −2.8 | 0.624 | 24.5 | 0.000147 |
| GM-CSF | Iso × R (µg) | −2.95 | 0.8635 | 43.9 | 0.00138 |
| GM-CSF | Iso × R × g | −6.5 | 1.5547 | 32.9 | 0.000202 |
| GM-CSF | R (µg) | 2.85 | 0.4337 | 16.1 | 6.28 × 10−6 |
| GM-CSF | R × g | 4.15 | 0.9974 | 18.5 | 0.000556 |
| IL-10 | Iso (µg, R) | −3.05 | 0.6062 | 7.7 | 0.00114 |
| IL-10 | Iso (µg) | −1.5 | 0.4324 | 36.2 | 0.00137 |
| IL-10 | R (µg) | 2.9 | 0.3257 | 19.9 | 2.26 × 10−8 |
| IL-12p70 | Iso (µg, R) | 0.2468 | 0.0496 | 8.39 | 0.000941 |
| IL-12p70 | Iso × R (µg) | 0.171 | 0.049 | 15.4 | 0.0032 |
| IL-12p70 | R (µg) | −0.2024 | 0.0416 | 18.8 | 0.000111 |
| IL-13 | Iso (µg, R) | −3.55 | 0.4825 | 90.5 | 8.18 × 10−11 |
| IL-13 | Iso (1g) | −2.8 | 0.5063 | 68.6 | 5.42 × 10−7 |
| IL-1B | Iso (µg, R) | −2.4713 | 0.5444 | 13.6 | 0.000493 |
| IL-1B | Iso (1g) | −0.9541 | 0.214 | 73.4 | 0.0000292 |
| IL-1B | Iso × R (µg) | −2.1307 | 0.5551 | 12.8 | 0.0021 |
| IL-1B | R (µg) | 2.709 | 0.4346 | 11.7 | 0.0000485 |
| IL-2 | µg | −0.1161 | 0.0403 | 106 | 0.00475 |
| IL-2 | Iso (µg. R) | −0.2931 | 0.0611 | 20.6 | 0.000103 |
| IL-2 | Iso (1g) | −0.1642 | 0.0402 | 48 | 0.000164 |
| IL-2 | R (µg) | 0.2543 | 0.0444 | 51.2 | 5.46 × 10−7 |
| IL-2 | R × g | 0.3121 | 0.0776 | 22.8 | 0.000542 |
| IL-4 | Iso (µg, R) | −0.1665 | 0.0475 | 12 | 0.00432 |
| IL-4 | Iso (µg) | −0.0993 | 0.0326 | 29.2 | 0.00488 |
| IL-4 | R (µg) | 0.1426 | 0.0414 | 44.9 | 0.00124 |
| IL-5 | Iso (µg, R) | −4.4 | 0.5475 | 29.3 | 6.85 × 10−9 |
| IL-5 | Iso (1g) | −3.1 | 0.7242 | 29.5 | 0.000181 |
| IL-5 | Iso × R × g | −5.9 | 1.5538 | 23 | 0.000932 |
| IL-5 | R (µg) | 2.4 | 0.5134 | 60.8 | 0.0000168 |
| IL-6 | Iso (µg, R) | −3.7 | 0.7387 | 8.3 | 0.000933 |
| IL-6 | Iso (µg) | −2.3 | 0.3979 | 240 | 2.30 × 10−8 |
| IL-6 | Iso (1g) | −3.4 | 0.587 | 11.1 | 0.000115 |
| IL-6 | R (µg) | 2.3 | 0.3138 | 41.5 | 5.26 × 10−9 |
| IL-7 | µg | 0.0751 | 0.0154 | 73.1 | 6.50 × 10−6 |
| IL-7 | Iso (µg, R) | 0.1521 | 0.0246 | 23.2 | 2.47 × 10−6 |
| IL-7 | Iso (1g) | 0.1062 | 0.0216 | 23.3 | 0.0000547 |
| IL-7 | Iso × g | −0.0889 | 0.023 | 30.5 | 0.000532 |
| IL-7 | Iso × R (µg) | 0.1348 | 0.0289 | 23.2 | 0.000108 |
| IL-7 | Iso × R × g | 0.2149 | 0.0417 | 20.5 | 0.0000453 |
| IL-7 | R (µg) | −0.161 | 0.0216 | 30.3 | 2.47 × 10−8 |
| IL-7 | R × g | −0.1724 | 0.0254 | 36.2 | 6.06 × 10−8 |
| IL-8 | Iso (µg, R) | −3.2 | 0.5387 | 21.8 | 5.82 × 10−6 |
| IL-8 | R (µg) | 2.5 | 0.6377 | 53.7 | 0.000252 |
| TNFα | Iso (µg, R) | −4 | 0.4773 | 16.4 | 2.48 × 10−7 |
| TNFα | Iso (µg) | −2.9 | 0.511 | 26.6 | 5.24 × 10−6 |
| TNFα | Iso (1g) | −4.2 | 0.5913 | 24.1 | 2.38 × 10−7 |
| TNFα | R (µg) | 2.7 | 0.4469 | 22.6 | 3.96 × 10−6 |
| TNFα | R × g | 2.8 | 0.693 | 10.2 | 0.00227 |
Controlling the false-discovery rate (FDR) to 1% corresponded to a p-value threshold of 0.0049, which in turn led to the identification of 49 significant contrasts among the 144 that were estimated. n = 10 independent experiments. cyt = cytokine, Iso = isoproterenol, R = 2 Gy radiation, g = gravity, p-value threshold p < 0.0049 after controlling the FDR to 1%. diff = estimated difference, se = standard error, df = degrees of freedom.