Figure 4.

Optimal radiation fractionation and dose per fraction for immune activation. Dependence of the model predicted overall tumor burden at Day 32, i.e., $V_1\left(32\mathrm{days}\right)+V_2\left(32\mathrm{days}\right)$, for different total (A) and biologically effective doses (B) for various numbers of fractions. Radiation is delivered daily, and three concurrent doses of 9H10 immunotherapy are applied at different times [11]. (C,D) Optimal number of radiation fractions and corresponding doses per fraction depending on the prescribed total and biologically effective doses. We assume that 9H10 immunotherapy is applied on Days 12,15 and 18.