r
|
Viable cancer cells volume doubling time |
1/day |
0.195 |
K
|
Tumor carrying capacity |
mm3
|
1423.1 |
a
|
CTLs’ killing rate |
mm3/(cell·day) |
0.0177 |
d
|
Clearance rate of dying cells |
1/day |
0.264 |
|
Fraction of viable cancer cells that survive |
|
|
|
after radiation dose |
|
|
|
Gy |
- |
0.265 |
|
Gy |
- |
0.664 |
|
Gy |
- |
0.783 |
|
Fraction of cells that will undergo |
|
|
|
immunogenic cell death after |
|
|
|
radiation dose |
|
|
|
Gy |
- |
0.194 |
|
Gy |
- |
0.984 |
|
Gy |
- |
0.367 |
l
|
Decay rate of effector cells |
1/day |
0.03 |
w
|
Baseline T cell recruitment rate |
cell/ (mm3·day) |
0.135 |
|
Fold change in the baseline T cell recruitment |
|
|
|
rate due to immunogenic cell death |
- |
15.37 |
e
|
Initial fold change in recruitment |
|
|
|
of cytotoxic T cells caused by the administered |
|
|
|
dose of 9H10 immunotherapy |
- |
8.495 |
|
9H10 immunotherapy clearance rate |
1/day |
0.967 |