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. 2018 Oct 29;19(11):3377. doi: 10.3390/ijms19113377

Table 1.

Model (Equations (3)–(10)) parameters and derived values.

Parameter Description Unit Value
r Viable cancer cells volume doubling time 1/day 0.195
K Tumor carrying capacity mm3 1423.1
a CTLs’ killing rate mm3/(cell·day) 0.0177
d Clearance rate of dying cells 1/day 0.264
SFD Fraction of viable cancer cells that survive
after radiation dose
D=20 Gy - 0.265
D=8 Gy - 0.664
D=6 Gy - 0.783
AID Fraction of cells that will undergo
immunogenic cell death after
radiation dose
D=20 Gy - 0.194
D=8 Gy - 0.984
D=6 Gy - 0.367
l Decay rate of effector cells 1/day 0.03
w Baseline T cell recruitment rate cell/ (mm3·day) 0.135
w2 Fold change in the baseline T cell recruitment
rate due to immunogenic cell death - 15.37
e Initial fold change in recruitment
of cytotoxic T cells caused by the administered
dose of 9H10 immunotherapy - 8.495
clr 9H10 immunotherapy clearance rate 1/day 0.967