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NMP prevents the BMP-2 induced increase in sclerostin expression. Stimulation of UMR-106 cells with 500 ng/mL bone morphogenetic protein 2 (BMP-2) increases sclerostin protein at 8 h (A) whereas a combination of BMP-2 and 2 mM NMP decreases sclerostin protein. Illustration of qRT-PCR of the same treatment is presented in (B).
