Table 3.

Anamorelin treatment effect size on the 12 individual items of the FAACT A/CS domain.

Individual Item	Overall Patient Population			Patients with BMI <20 kg/m2 at Baseline
	Mean (95% CI)	Standardized Effect Size	p Value	Mean (95% CI)	Standardized Effect Size	p Value
I am concerned about how thin I look	0.41 (0.218, 0.601)	0.317	0.000	0.53 (0.083, 0.976)	0.375	0.018
I am worried about my weight	0.29 (0.086, 0.493)	0.213	0.005	0.37 (–0.091, 0.831)	0.253	0.110
My family or friends are pressuring me to eat	0.23 (0.025, 0.454)	0.163	0.029	0.72 (0.253, 1.186)	0.424	0.002
The amount I eat is sufficient to meet my needs	0.16 (–0.011, 0.331)	0.139	0.064	0.54 (0.168, 0.911)	0.451	0.005
Most food tastes unpleasant to me	0.16 (–0.036, 0.356)	0.117	0.117	0.39 (–0.072, 0.852)	0.254	0.109
I have pain in my stomach area	0.15 (–0.001, 0.301)	0.149	0.046	0.36 (–0.057, 0.777)	0.273	0.085
I have a good appetite	0.12 (–0.063, 0.303)	0.094	0.210	0.31 (–0.115, 0.735)	0.218	0.167
My interest in food drops as soon as I try to eat	0.11 (–0.075, 0.295)	0.085	0.256	0.6 (0.165, 1.034)	0.424	0.008
I have been vomiting	0.08 (–0.054, 0.214)	0.088	0.239	0.2 (–0.1, 0.5)	0.206	0.193
When I eat, I seem to get full quickly	0.04 (–0.148, 0.228)	0.036	0.630	0.46 (–0.037, 0.957)	0.302	0.057
My general health is improving	0.04 (–0.148, 0.228)	0.032	0.669	0.35 (–0.095, 0.795)	0.256	0.106
I have difficulty eating rich or “heavy” foods	0.02 (–0.187, 0.227)	0.015	0.845	0.44 (–0.038, 0.918)	0.297	0.061

A/CS, Anorexia/Cachexia Subscale; BMI, body mass index; CI, confidence interval; FAACT, Functional Assessment of Anorexia/Cachexia Therapy.