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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Neuropharmacology. 2018 Sep 18;143:79–94. doi: 10.1016/j.neuropharm.2018.09.016

Fig. 4. Freezing time is elevated in Stay mice during SAM interaction and can be increased by Orx2 receptor antagonism and decreased by Orx2 receptor agonism.

Fig. 4.

A) Mean (± SEM) contextual freezing time in vehicle treated Stay animals (solid dots) is significantly increased (*) compared to day one on days 2–4 of SAM interaction; and compared to vehicle treated Escape mice (square ‡) on injection day (3; arrow ‡). B) Mean (± SEM) % freezing time increases in all groups on day 2, compared to day 1, prior to treatment (+ significance in agonist treated animals, # significance in antagonist treated animals). Injection of Orx2 antagonist (icv; triangles) increased freezing on day 3 compared to day 1, day 2, and day 4, and icv Orx2 agonist (diamonds, arrow) significantly decreased freezing relative to vehicle (§) and antagonist treatments (†) on day 3 (arrow).