Skip to main content
. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: J Immunol. 2018 Oct 29;201(11):3320–3328. doi: 10.4049/jimmunol.1800670

Figure 1.

Figure 1.

Profound thymus involution in Klotho-deficient (Kl/Kl) mice at 8 weeks of age.

(A) A representative image of the thymus from Kl/Kl and littermate control mice at 4 and 8 weeks of age. (B) Quantification of total thymocytes in Kl/Kl mice and littermate controls. (C) A summary of percentages of thymocyte subpopulations, including DN (Lineage-CD4-CD8-), DP (CD4+CD8+), CD4SP (TCRβ+CD4+CD8-) and CD8SP (TCRβ+CD4-CD8+) cells. (D) A graph shows quantification data of absolute numbers of thymocyte subpopulations. (E) Frequencies of semi-mature (CD69+MHC-I-) and mature (CD69+/−MHC-I+) subpopulations in CD4SP cells. (F) Quantification of absolute numbers of semi-mature and mature CD4SP in the thymi. Each symbol in the graphs represents an individual mouse (n ≥ 5); small horizontal lines indicate the group mean (± s.d.). ns, not significant (P ≥ 0.05); *, P < 0.05.