FIG 1.

Mediator associates with sn/snoRNA genes. (A) Genome browser view of the RPM-normalized Med8, Med14, and Med3 ChEC-seq signal at a representative sn/snoRNA-containing region of the yeast genome. (B) Average plot of the Med8, Med14, Med3, and free MNase ChEC-seq signal at 58 sn/snoRNA genes. (C) Heatmaps of the Med8, Med14, and Med3 ChEC-seq signal at 58 sn/snoRNA genes sorted in descending order by average Med8 signal. Heatmaps were log₂ transformed with a center of 5 and are displayed with a contrast value of 3. (D) Genome browser view of the MetaMediator ChIP-chip signal in 1-NA-PP1-treated WT and kin28as cells at a representative sn/snoRNA-containing region of the yeast genome. (E) Average plot of the MetaMediator ChIP-chip signal in 1-NA-PP1-treated WT and kin28as cells at sn/snoRNA genes. (F) Heatmaps of the MetaMediator ChIP-chip signal at sn/snoRNA genes in WT and kin28as cells sorted in descending order by average WT signal. Heatmaps were not log₂ transformed, as the raw data were provided in this form, and are displayed with a contrast value of 10. chr, chromosome.