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Med14 destabilization reduces TFIIB binding to sn/snoRNA promoters. (A) Box plots of the RPM-normalized log2(3-IAA/DMSO) TFIIB ChIP-seq signal at 58 sn/snoRNA genes and the top 1,000 most highly RNAPII-occupied mRNA genes in WT and Med14-AID strains and the log2(Med18-AA/WT) TFIIB ChIP-chip signal at sn/snoRNA and mRNA genes. (B) Genome browser view of the TFIIB ChIP signal with and without Med14 or Med18 depletion at a representative snRNA locus.
