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. 2018 Nov 26;9:2735. doi: 10.3389/fimmu.2018.02735

Table 2.

The influence of cell surface proteins of T cells on the outcome of HIV-1 infection.

Genes or products Population Phenotypes References
CD8+ Dominant TCR Clonotypes Elite; LTNP Better duration; Cross reactivity (8789)
KK10-specific TCR clonotype
BV27-CASSGGRRAF/J1-1
Elite vs. Progressors (4% vs. 20%) Less effective (87)
KK10-specific TCR clonotype
BV21-CASTNRGSEQY/J2-7
Elite vs. Progressors (4% vs. 17.7%) Less effective (87)
Preservation of CD73 on cells Elite Normal function (90)
Up regulation of PD-1 LTNPs vs. TP (16.3% vs. 45.2%) Reduced CD4+ T cells; Increased VLs (91, 92)
Increase of HLA-G+ Controllers Higher CD4+ T cells; Lower VLs (93)
CD4+ Gag293-specific TCR clonotype TRAV24 Controller vs. treated patients (44% vs. 13%) Superior functions (94)
Gag293-specific TCR clonotype TRBV2 Controller vs. treated patients (82% vs. 28%) Superior functions (94)
CD45RA+CCR7 LTNPs IFN-γ secreting (95)
Depletion of CD73+ on cells Progressors Reduced CD4+ T cells (96)
Frequency of Tregs of CD45RA+CD27CCR7 CD62L and CD45RACD27CCR7CD62L ART population Higher VLs within total CD4+ T cells (97)
CTLA-4 on Tregs Infected population Corresponding to stages of disease (98)
ICOS on Tregs Infected population Corresponding to stages of disease (98)
Steady CD39 on Tregs Elite Stable CD4+ T cells; (98)
Preserved Vγ2Vδ2
β7Hi
NVSs
Progressors
Suppressed VLs; Higher CD56
Higher risk of infection; More rapid progression
(99)
(100)