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. 2018 Nov 26;9:2728. doi: 10.3389/fimmu.2018.02728

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Copyright © 2018 Menard, Fischer, Kakrecha, Linsley, Wambre, Liu, Rust, Lee, Penhallow, Manjarrez Orduno and Nadler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DP T cells appear to be a subset of CD8+ T cells. (A) Representative example of a SPADE-tree generated with surface markers (CD4, CD8, TIGIT, ICOS, TIM-3, PD-1, CD45RO, OX40, GITR, CCR7) on the replication cohort in the 10 samples with >5% DP T cells (red circle and arrow indicate zone where DP T cells cluster). The size of the nodes represents the number of cells, and the color represents the transformed median expression level of CD8 (left panel) or CD4 (right panel). (B) Representative dot plot of CD45RO (x-axis) and CCR7 (y-axis) in CD4+, CD8+, and DP gated T cells. (C) Summary of cell frequencies in each quadrant shown in (B) for DP T cells from RCC samples with >5% DP cells (replication cohort).