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. 2018 Nov 26;9:1694. doi: 10.3389/fphys.2018.01694

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Copyright © 2018 Witowski, Kamhieh-Milz, Kawka, Catar and Jörres.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Induction by IL-17 of mediators with angiogenic activity in mesothelial cells. The mechanism behind IL-17 induction of angiogenesis is poorly understood. It may involve the secretion of chemokines with angiogenic activity by mesothelial cells stimulated with IL-17 (Mechanism I). It may also be related to IL-17-induced mesothelial production of IL-6, which may then form a complex with sIL-6R, stimulating VEGF synthesis (Mechanism II). Other, so far unknown scenario(s), cannot be excluded (Mechanism III).