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. 2018 Nov 9;94(9):337–349. doi: 10.2183/pjab.94.022

Figure 4.

Figure 4.

Actin-dependent forces during cell migration. (a) In migrating neurons with a long leading process, the nucleus is either pushed or pulled by actomyosin-driven forces, depending on myosin II localization. (b) Mesenchymal cells move the nucleus rearward by the retrograde flow of TAN lines at the onset or reorientation of migration. (c) Some immune cells and cancer cells pass through submicron pores between vascular endothelial cells. The nucleus is covered by actin meshwork and is protected from damage caused by strong shear stress at the constriction.