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Proposed roles of ArsK and ArsR2 in As(III), Sb(III), Rox(III), and MAs(III) transport and resistance. As(III), Sb(III), Rox(III), or MAs(III) is taken up into the cells and then interacts with ArsR2. The altered conformation of ArsR2 releases its suppression of the arsR2-arsK operon, and then the arsK gene is expressed. ArsK specifically catalyzes the efflux of As(III), Sb(III), Rox(III), and MAs(III) out of the cells.
