Table 2. Diagnostic accuracy of immunological synapse genes.
| Gene | AUROC | |||||
|---|---|---|---|---|---|---|
| Area | 95% CI | P | OPP copies/ng total mRNA | Sensitivity | Specificity | |
| CD1C | 0.838 | 0.719–0.957 | <0.001 | 30.40 | 0.765 | 0.792 |
| CD40LG | 0.821 | 0.695–0.948 | 0.001 | 50.60 | 0.882 | 0.708 |
| ICOS | 0.793 | 0.654–0.931 | 0.002 | 38.00 | 0.706 | 0.750 |
| CD28 | 0.778 | 0.637–0.919 | 0.003 | 102.00 | 0.824 | 0.667 |
| CD3E | 0.743 | 0.593–0.892 | 0.009 | 22.60 | 0.765 | 0.625 |
| IL2RA | 0.733 | 0.573–0.892 | 0.012 | 20.80 | 0.765 | 0.667 |
| CCR7 | 0.707 | 0.549–0.866 | 0.025 | 158.60 | 0.882 | 0.541 |
AUROC for differential diagnosis between patients with VAP and MVCs are presented here. Results for gene expression levels are provided as cDNA copies/ng total mRNA. OPP, optimal operating point; AUROC, areas under receiving operating curves; VAP, ventilator-associated pneumonia; MVC, mechanical ventilation control.