Table 2.
Biofilm inhibitory concentrations of QA and UDA (individual or in combination) against Candida spp.
| Candida strain | BIC of individual Compound (μg mL-1) |
BIC of compounds in combination (μg mL-1) |
FICI | ||
|---|---|---|---|---|---|
| QA | UDA | QA | UDA | ||
| C. albicans ATCC 90028 | 400 | 20 | 100 | 5 | 0.5–1.0 |
| C. albicans MTCC 186 | 400 | 40 | 100 | 10 | 0.5–1.0 |
| C. glabrata MTCC 3019 | 400 | 40 | 100 | 10 | 0.5–1.0 |
| C. tropicalis MTCC 184 | 800 | 80 | 200 | 20 | 0.375–1.0 |
| CA1 | 400 | 40 | 100 | 10 | 0.5–1.0 |
| CA2 | 400 | 40 | 100 | 10 | 0.375–1.0 |
| CA3 | 400 | 40 | 100 | 10 | 0.5–1.0 |
| CA4 | 400 | 40 | 100 | 10 | 0.5–1.0 |
| CT1 | 800 | 80 | 200 | 20 | 0.5–1.0 |
| CT2 | 800 | 80 | 200 | 20 | 0.5–1.0 |
| CT3 | 800 | 80 | 200 | 20 | 0.5–1.0 |
BIC, biofilm inhibitory concentration; FICI, fractional inhibitory concentration index; QA, quinic acid; UDA, undecanoic acid. QA-UDA combination has a significant reduction in BIC than QA or UDA alone by Student’s t-test (p < 0.005).