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. 2018 Nov 26;8:550. doi: 10.3389/fonc.2018.00550

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Copyright © 2018 Arruga, Vaisitti and Deaglio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NOTCH signaling in B cell development. In bone marrow-residing CLPs, NOTCH1 signaling must be switched off to allow proper B cell development. On the contrary, after migration of immature B cells to the spleen, interaction of DLL1 with NOTCH2, with the involvement of recombinant signal binding protein for immunoglobulin kJ region (RBPJk), induces NOTCH signaling in transitional B (T2) cells to specify marginal zone B cells, as opposed to follicular B cells. NOTCH2 signaling is also necessary for CLPs to differentiate toward B1 cells.