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. Author manuscript; available in PMC: 2018 Dec 3.
Published in final edited form as: Exp Neurol. 2018 Jan 31;302:196–204. doi: 10.1016/j.expneurol.2018.01.014

Fig. 2.

Fig. 2

PTPσ inhibits activation of immune cells and development of autoimmune diseases, including colitis and EAE. PTPσ deficiency induces activation of DCs (cDC and pDC), differentiation of CD4+ T cells into specific Th1 and Th17 cells, infiltration of leukocytes and generation of pro-inflammatory related cytokines including IFN. Thus, PTPσ inhibition facilitates development of autoimmune diseases, such as colitis and CNS autoimmune demyelinating disease EAE.