Table 4.
Predictors of Myelosuppression in Children Chronically on Glucocorticoids
| Variable | Univariate OR (95% CI) | P | Multivariate OR (95% CI) | P |
|---|---|---|---|---|
| Trimethoprim-sulfamethoxazole exposure | 2.01 (1.70–2.38) | <.001 | 1.85 (1.56–2.20) | <.001 |
| Current glucocorticoid exposurea | 1.77 (1.55–2.03) | <.001 | 1.66 (1.44–1.90) | <.001 |
| Additional immunosuppressant exposure | 8.34 (7.24–9.61) | <.001 | 6.75 (5.78–7.88) | <.001 |
| Age | 1.04 (1.03–1.05) | <.001 | 1.02 (1.01–1.03) | <.001 |
| Sex (female) | 0.72 (0.66–0.78) | <.001 | 0.78 (0.72–0.85) | <.001 |
| Race | ||||
| White | Reference | Reference | ||
| Black | 1.33 (1.18–1.51) | <.001 | 1.35 (1.19–1.54) | <.001 |
| Hispanic | 1.82 (1.63–2.03) | <.001 | 1.91 (1.70–2.14) | <.001 |
| Asian | 1.57 (1.28–1.92) | <.001 | 1.66 (1.35–2.04) | <.001 |
| Geographic regionb | ||||
| 1 | Reference | Reference | ||
| 2 | 0.66 (0.58–0.76) | <.001 | 0.70 (0.60–0.80) | <.001 |
| 3 | 0.72 (0.63–0.81) | <.001 | 0.73 (0.64–0.82) | <.001 |
| 4 | 0.68 (0.57–0.81) | <.001 | 0.62 (0.52–0.74) | <.001 |
Abbreviations: CI, confidence interval; OR, odds ratio.
aCurrent glucocorticoid exposure indicates that the patient filled a prescription for glucocorticoid in the same month in which they had the outcome.
bRegions according to the US Census: Region 1, CT, MA, ME, NH, NJ, NY, PA, RI, and VT; region 2, IA, IL, IN, KS, MI, MN, MO, NE, ND, OH, SD, and WI; Region 3, AL, AR, DE, DC, FL, GA, KY, LA, MD, MS, NC, OK, SC, TN, TX, and VA; and Region 4, AK, AZ, CA, CO, HI, ID, MT, NM, NV, OR, WA, and WY.