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. 2018 Sep 21;21(12):1114–1127. doi: 10.1093/ijnp/pyy084

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© The Author(s) 2018. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Enriched housing attenuated glial reactivation in the hippocampus of socially isolated (SI) aged mice. (A,B) Representative images showing expression and distribution of glial fibrillary acidic protein (GFAP)-positive astrocytes (A) and Iba-1 positive microglia (B) in the medial prefrontal cortex (mPFC) and hippocampus of mice with 4 different housing patterns. (C,D) The percentage of GFAP (C) and Iba-1 (D) positive areas in the mPFC and hippocampus, respectively. Enriched housing resulted in a significantly decreased percentage of positive area for GFAP or Iba-1 in the hippocampus but not mPFC of isolated mice. Housing (GFAP: mPFC, F_1,12=16.780, P=.001; hippocampus, F_1,12=39.400; Iba-1: mPFC, F_1,12=31.869, P<.001; hippocampus, F_1,12=10.057, P=.008); environment (GFAP: mPFC, F_1,12=2.488, P=.141; hippocampus, F_1,12=7.007, P=.021 Iba-1: mPFC, F_1,12=2.597, P=.133; hippocampus, F_1,12=10.674, P=.007); interaction effects (GFAP: mPFC, F_1,12=0.595, P=.456; hippocampus, F_1,12=1.553, P=.237; Iba-1: mPFC, F_1,12=0.000, P=.994; hippocampus, F_1,12=4.062, P=.067). #P<.05; ##P<.01, SI housing vs group housing (GR); *P<.05, enriched environment (EE) vs standard environment (SE). Data were analyzed by ANOVA with 2-way Tukey’s posthoc test and expressed as mean±SEM from 4 mice per group.