Skip to main content
. 2018 Aug 31;21(12):1109–1113. doi: 10.1093/ijnp/pyy080

Figure 1.

Figure 1.

Chronic intermittent cold (CIC) stress induced a reversal learning deficit in female rats that was corrected by acute ketamine treatment. (A) In experiment 1, CIC stress increased the number of trials required to reach criterion in the reversal learning task compared with nonstressed controls (*P<.05). Data presented as mean±SEM (n=4–6 per group). (B) In experiment 2, CIC stress again increased the number of trials required to reach criterion in the reversal learning test (*P<.01 compared with nonstressed vehicle-treated controls). Acute systemic injection of ketamine (10mg/kg, i.p.) given 24hours prior to testing corrected this deficit (+P<.01 compared with CIC-stressed vehicle-treated group). Data presented as mean±SEM (n=6–7 per group).