Figure 2.

Chronic intermittent cold (CIC) stress increased the expression of PSD95 in the orbitofrontal cortex (OFC) of female rats, and this effect was attenuated after ketamine administration. PSD95 protein expression was significantly elevated in the OFC of CIC-stressed female rats (*P<.02 compared with nonstressed vehicle-treated controls). Ketamine attenuated this effect, as 2 hours after acute systemic ketamine administration (10mg/kg, i.p.), PSD95 expression in the OFC of stressed rats was not different from that in either unstressed rats receiving ketamine (P=.92) or in unstressed vehicle controls (P=.09). Data presented as mean±SEM (n=3–5 per group).