Figure 5.

In vivo NIR laser-controlled photothermal effects and PAI capacity of DOX@CAuNCs. (A) Infrared thermography of tumor tissues of H22 tumor-bearing mice recorded by an IR camera at 24 h after intravenous injection with different formulations at Au dose of 10 mg/kg (the corresponding DOX dose was 15 mg/kg), followed with 808 nm laser irradiation (1 W/cm²) for different time intervals at the tumor sites. (B) Temperature change profiles of the above four NIR laser-irradiated groups. (C) In vivo PA imaging in H22 tumor-bearing mice at different time intervals after intratumoral injection with AuNCs or CAuNCs at Au dose of 10 mg/kg. (D) Relative photoacoustic intensity as indicated in C. Data as mean value ± SD (n=3). *P<0.05, **P<0.01, ***P<0.001.