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. 2018 Oct 22;8(19):5276–5288. doi: 10.7150/thno.27847

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The blood levels of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT) illustrating liver function (A), creatine kinase (CK) illustrating heart and skeletal muscle function (A), and blood urea nitrogen (BUN) illustrating kidney function (B) in non-treated mice (0 h) and mice subcutaneously injected with FS-344 mRNA-loaded nanoparticles (0.5 mg/kg), assessed at different time points. (C) Expressions of inflammatory genes in the livers of non-treated mice (control) and mice injected every 72 h for 8 weeks with the FS-344 mRNA-loaded nanoparticles (0.5 mg/kg).