Figure 6.

Percent change in lean muscle mass (A) and fat mass (B) from baseline in non-treated mice (control) and mice treated with FS-344 mRNA-loaded nanoparticles (0.5 mg/kg). Wild-type 17-week-old C57BL/6L mice were subcutaneously injected with either saline (control) or the nanoparticles every three days for 8 weeks. The lean and fat mass values obtained prior to treatment were used as a baseline for subsequent analyses. The average baseline values were not significantly different among the treatment and control groups. *p < 0.05 when compared with non-treated animals. (C) Average weights of gastrocnemius and triceps muscles resected from non-treated and treated mice. *p < 0.05 when compared with tissue weights resected from non-treated mice. (D) Photographs of hind leg muscles of non-treated and treated mice. The red arrows denote the gastrocnemius muscles.