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. 2018 Oct 29;8(19):5469–5481. doi: 10.7150/thno.28295

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Scheme 1 — (A) The structural composition and preparation of B6ME-NPs. DSPE-PEG-B6, DSPE-PEG-MA and DSPE-PEG-phenylboronic acid were used to improve the biocompatibility of magnetic nanoparticles through a micelle formation procedure. EGCG was then grafted onto the surface of the nanoparticles through the formation of a boronate ester bond. (B) The schematic diagram of B6ME-NPs in vivo: (1) B6ME-NPs target TfR on BBB and cross the BBB. (2) The NPs can target DAT and accumulate in the lesions area. (3) The NPs are internalized by dopaminergic neurons via DAT. (4) EGCG is released from the NPs due to high ROS response. (5) Free EGCG inhibits αS aggregation. (6) The high concentration of EGCG induces flotillins, the formation of membrane curvature and vesicle budding.