TABLE 1.
SNP | Location | Chromosome | Gene | Nucleotide change | Type/comment | pa | MAF |
---|---|---|---|---|---|---|---|
rs1801133 | 11856378 | 1 | MTHFR | C→T | Exon, nonsynonymous | .271 | 0.418 |
rs1476413 | 11852300 | 1 | MTHFR | A→G | Intron | .826 | 0.147 |
rs7560488 | 25568821 | 2 | DNMT3A | C→T | Validated | .890 | 0.189 |
rs828903 | 74209594 | 2 | MTHFD2 | A→G | Intron | .598 | 0.361 |
rs7340453 | 74200888 | 2 | MTHFD2 | C→T | Intron | .987 | 0.390 |
rs70991108 | 80654344 | 5 | DHFR | Deletion→insertion | Intron | .813 | 0.083 |
Note. SNP, single nucleotide polymorphisms; MAF, minimum allele frequency; MTHFR, 5,10-methylenetetrahydrofolate reductase; DNMT3A, DNA (cytosine-5)-methyltransferase-3A; MTHFD2, bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; DHFR, dihydrofolate reductase.
p value of Hardy-Weinberg.