TABLE 1.

Selected variants in folate pathway genes

SNP	Location	Chromosome	Gene	Nucleotide change	Type/comment	pa	MAF
rs1801133	11856378	1	MTHFR	C→T	Exon, nonsynonymous	.271	0.418
rs1476413	11852300	1	MTHFR	A→G	Intron	.826	0.147
rs7560488	25568821	2	DNMT3A	C→T	Validated	.890	0.189
rs828903	74209594	2	MTHFD2	A→G	Intron	.598	0.361
rs7340453	74200888	2	MTHFD2	C→T	Intron	.987	0.390
rs70991108	80654344	5	DHFR	Deletion→insertion	Intron	.813	0.083

Note. SNP, single nucleotide polymorphisms; MAF, minimum allele frequency; MTHFR, 5,10-methylenetetrahydrofolate reductase; DNMT3A, DNA (cytosine-5)-methyltransferase-3A; MTHFD2, bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; DHFR, dihydrofolate reductase.

^ap value of Hardy-Weinberg.