Table 2.

Cerebral and cerebellar fMRI activation differences between control and SCA6 groups

Brain region (s)	Side	Size (mm3)	MNI coordinates (Peak)			F value
			x	y	z
Whole brain analysis
CON > SCA6
Middle frontal gyrus; PMv	I	1728	45	30	36	9.04
Superior frontal gyrus	C	1701	−27	51	18	15.70
	C	324	−18	66	21	24.02
Putamen	C	1161	−24	9	−6	16.11
Caudate nucleus	C	567	−24	−3	18	21.32
SMA, preSMA	C	378	−2	−6	72	12.38
	I	351	3	−3	57	11.99
Precentral gyrus; M1	C	918	−24	−21	74	13.93
	C	621	−30	−24	51	16.19
	I	324	27	−15	72	20.02
Postcentral gyrus; S1	C	432	−33	−36	69	9.88
	I	1161	39	−31	63	8.99
Superior parietal lobule	C	378	−36	−48	69	12.05
Middle cingulate cortex	C	351	−9	−30	51	33.41
SCA6 > CON	I	324	12	−90	−12	10.69
Temporal pole	I	486	51	21	−18	18.93
Lingual gyrus	I	324	12	−90	−12	10.69
SUIT analysis: cerebellum	I	324	12	−90	−12	10.69
CON > SCA6	I	324	12	−90	−12	10.69
Vermis VI, lobule I-IV, V, VI		6248	0	−66	−17	28.76
Crus I-II, VIIb, vermis VIIIa/b	C	6048	−12	−80	−45	28.23

C contralateral hemisphere, CON control, I ipsilateral hemisphere, M1 primary motor cortex, MNI Montreal Neurological Institute, PMv ventral premotor, S1 primary somatosensory cortex, SMA supplementary motor area, SCA6 spinocerebellar ataxia type 6