Table 4.
Correlation between structural and functional changes in brain and ataxia severity
| Brain region (s) | ICARS kinetic | ICARS total | SARA total |
|---|---|---|---|
| BOLD: percent signal change (MNI Coordinates) | |||
| cM1 (−24, −21, 74) | −0.698* (PFDR = 0.02) | −0.715* (PFDR = 0.03) | −0.710* (PFDR = 0.04) |
| cM1 (−30, −24, 51) | −0.443 (PFDR = 0.19) | −0.407 (PFDR = 0.24) | −0.476 (PFDR = 0.14) |
| iM1 (27, −15, 72) | −0.676* (PFDR = 0.03) | −0.618* (PFDR = 0.04) | −0.632* (PFDR = 0.04) |
| cSMA, preSMA (−2, −6, 72) | −0.718* (PFDR = 0.02) | −0.618* (PFDR = 0.04) | −0.598 (PFDR = 0.05) |
| iSMA (3, −3, 57) | −0.723* (PFDR = 0.02) | −0.633* (PFDR = 0.04) | −0.667* (PFDR = 0.04) |
| cS1 (−33, −36, 69) | −0.802* (PFDR = 0.02) | −0.736* (PFDR = 0.03) | −0.699* (PFDR = 0.04) |
| iS1 (39, −31, 63) | −0.376 (PFDR = 0.27) | −0.302 (PFDR = 0.39) | −0.335 (PFDR = 0.32) |
| Vermis VI, Lobule V-VI (0, −66, −17) | −0.172 (PFDR = 0.60) | −0.084 (PFDR = 0.86) | −0.011 (PFDR = 1.00) |
| Crus I-II, VIIb, Vermis VIIIa/b (−12, −80, −45) | −0.197 (PFDR = 0.57) | −0.178 (PFDR = 0.67) | −0.157 (PFDR = 0.73) |
| Free-water | |||
| Dentate nucleus | 0.439 (PFDR = 0.19) | 0.582 (PFDR = 0.05) | 0.583 (PFDR = 0.06) |
| SCP | 0.572 (PFDR = 0.07) | 0.643* (PFDR = 0.04) | 0.636* (PFDR = 0.04) |
| MCP | 0.518 (PFDR = 0.12) | 0.579 (PFDR = 0.05) | 0.496 (PFDR = 0.13) |
| ICP | −0.222 (PFDR = 0.55) | 0.001 (PFDR = 1.00) | 0.002 (PFDR = 1.00) |
| Vermis | −0.112 (PFDR = 0.70) | 0.074 (PFDR = 0.86) | 0.102 (PFDR = 0.83) |
| Lobule V | 0.586 (PFDR = 0.07) | 0.630* (PFDR = 0.04) | 0.631* (PFDR = 0.04) |
| Lobule VI | 0.329 (PFDR = 0.33) | 0.359 (PFDR = 0.30) | 0.349 (PFDR = 0.32) |
Data are correlation coefficient (PFDR)
BOLD blood oxygen level-dependent, c contralateral, i ipsilateral, ICARS International Cooperative Ataxia Rating Scale, ICP inferior cerebellar peduncle, M1 primary motor cortex, MCP middle cerebellar peduncle, MNI Montreal Neurological Institute, PFDR corrected P value using a false discovery rate, S1 primary somatosensory cortex, SARA scale for the assessment and rating of ataxia, SCP superior cerebellar peduncle, SMA supplementary motor area
*
Indicates significant correlation (PFDR < 0.05)