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. 2018 Dec 3;18:195. doi: 10.1186/s12935-018-0694-9

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — CDK8 siRNA suppresses the proliferation of human glioma U251 cells. a CDK8 siRNA decreased the activity of U251 cells at 48 and 72 h. b CDK8 siRNA inhibited U251 cell proliferation. c Flow cytometric analysis showed the percentage of U251 cells in the G0/G1, S and G2/M phases. G0/G1 phase cells increased after CDK8 siRNA treatment, and S and G2/M phase cells were reduced. d The data showed the percentage of early and late apoptosis after CDK8 siRNA treatment. e The knockdown efficiency of CDK8 siRNA in U251 cells. f CDK8, β-catenin and cyclin D1 protein expression was examined after CDK8 siRNA treatment. *p < 0.01, n = 3