Fig. 6.

CDK8 overexpression rescues miR-770-induced cellular phenotypes in glioma cells. a U251 cell activity was measured after cotransfection with CDK8 and miR-770 vectors. b U251 cell proliferation was examined after cotransfection with CDK8 and miR-770 vectors. c Cell cycle was determined in U251 cells at 48 h. d Apoptosis was detected in U251 cells at 48 h. e CDK8 overexpression rescued CDK8 mRNA expression levels reduced by miR-770. f CDK8, β-catenin and cyclin D1 protein expression was examined after cotransfection with CDK8 and miR-770 vectors. *p < 0.01, compared with the vector control group; #p < 0.01, compared with the miR-770 overexpression group. n = 3