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. 2018 Dec 3;7:30. doi: 10.1186/s40035-018-0135-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — GM6-regulated genes encoding receptors and TFs. (a) Receptor-encoding genes most consistently up-regulated by GM6 across the 3 time points (6–48 h). (b) Receptor-encoding genes most consistently down-regulated by GM6 across the 3 time points (6–48 h). (c) TF-encoding genes most consistently up-regulated by GM6 across the 3 time points (6–48 h). (d) TF-encoding genes most consistently down-regulated by GM6 across the 3 time points (6–48 h). (e, f) Gene symbol clouds for genes encoding (e) receptors and (f) transcription factors. The size of each symbol corresponds to the significance of p-values across the three time points (6, 24 and 48 h; red = GM6-increased; blue = GM6-decreased). (g) Nerve growth factor receptor (NGFR) expression. (h) Fibroblast growth factor receptor like 1 (FGFRL1) expression. (i) 5-hydroxytryptamine receptor 1E (HTR1E) expression. (j) TNF receptor superfamily member 19 (TNFRSF19) expression. (k) Hes family bHLH transcription factor 7 (HES7) expression. (L) GLI family zinc finger 1 (GLI1) expression. (m) Kruppel like factor 11 (KLF11) expression. (n) Zinc finger protein 33B (ZNF33B) expression. In (g) – (n), letters shown for each bar indicate results from post hoc treatment comparisons (Fisher’s least significant difference), where treatments not sharing the same letter differ significantly (P < 0.05)