Table 1.
Main characteristics of the patients included
| cfDNA not reportable n = 58 |
cfDNA successful n = 295 |
p-value | |
|---|---|---|---|
| Maternal age (years) | 37 (35.7–40.1) | 34 (29.6–37.1) | < 0.001 |
| Maternal weight (kg) | 77 (60–90.3) | 64 (56–70) | < 0.001 |
| Maternal height (cm) | 165 (161.8–171) | 165 (161–169) | 0.53 |
| BMI | 29 (22.3–32.9) | 23.7 (20.7–25.9) | < 0.001 |
| Ethnic group | 0.14* | ||
| Caucasian | 41 (70.7) | 237 (80.3) | |
| Asian | 1 (1.7) | 13 (4.4) | |
| Black or Caribbean | 7 (12.1) | 41 (13.9) | |
| Other/unknown | 9 (15.5) | 4 (1.4) | |
| Cigarette smoker | 4 (6.9) | 1 (0.3) | |
| Nulliparous | 22 (37.9) | 18 (6.1) | < 0.001 |
| History of aneuploidy | 3 (5.2) | 9 (3.1) | |
| Medical condition | |||
| Autoimmune disease | 7 (12.1) | 5 (1.7) | < 0.001 |
| Repeated vein thrombosis | 8 (13.8) | 3 (1.0) | < 0.001 |
| Other chronic condition | 5 (8.6) | 35 (11.9) | 0.65 |
| Heparin received | 15 (25.9) | 20 (6.8) | < 0.001 |
| Antiplatelet therapy | 9 (15.5) | 24 (8.1) | 0.11 |
| Any other treatment receiveda | 14 (24.1) | 75 (25.4) | 0.96 |
| Mode of conception | 0.83 | ||
| Spontaneous | 50 (86.2) | 248 (84.1) | |
| Assisted | 8 (13.8) | 47 (15.9) | |
| Reason for referral | |||
| First-trimester screening | 40 (70.0) | 35 (11.9) | |
| Second-semester screening | 10 (17.2) | 1 (0.3) | |
| Maternal age | 4 (6.9) | 0 | |
| History of aneuploidy | 4 (6.9) | 1 (0.3) | |
| Ultrasound abnormalities | 0 | 19 (6.4) | |
| First line screening | 0 | 239 (81.0) | |
Data are given as mean (interquartile range) or n (%)
1 patient had a history of medical abortion for EDFR2 mutation
* Caucasian versus other ethnic group
aIncluding: nicardipine/hydroxychloroquine/digoxin/corticosteroids/chloroquine/levothyroxine