Table 3.
Logistic regression to predict non-reportable results of cfDNA testing
| Variable | N (%) or median (range) | Non-reportable cfDNA assay | |||
|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | ||||
| OR (95% CI) | p | OR (95% CI) | p | ||
| Maternal age (years) | 34 (18–49) | 1.105 (1.046–1.167) | < 0.001 | 1.006 (0.926–1.094) | 0.883 |
| Gestational age (weeks) | 12.6 (11.1–27.5) | 1.674 (1.436–1.953) | < 0.001 | 1.136 (0.936–1.380) | 0.198 |
| Maternal weight (kg) | 63 (43–110) | 1.046 (1.028–1.065) | < 0.001 | 1.034 (1.006–1.063) | 0.017 |
| High risk for down syndrome in maternal serum screeninga | |||||
| Yes | 60 (20.1) | 48.364 (21.319–109.714) | < 0.001 | 28.823 (9.757–85.146) | < 0.001 |
| No | 239 (79.9) | 1 | 1 | ||
| IVF | |||||
| Yes | 51 (16.1) | 0.639 (0.273–1.499) | 0.304 | ||
| No | 266 (83.9) | 1 | |||
| Patients treated with LMWH | |||||
| Yes | 35 (11.0) | 4.555 (2.176–9.535) | < 0.001 | 1.993 (0.539–7.377) | 0.301 |
| No | 282 (89.0) | 1 | 1 | ||
| Patients with autoimmune disease | |||||
| Yes | 12 (3.8) | 9.731 (2.825–33.528) | < 0.001 | 10.376 (1.618–66.526) | 0.014 |
| No | 305 (96.2) | 1 | 1 | ||
Italic values indicate significance of p value (p < 0.05)
LMWH low-molecular-weight heparin, IVF in vitro fertilization
aMissing data in 18 cases