Table 3.

Clinic pathologic factors associated with OS in the Cox hazard regression analysis for LGG and GBM patients from the CGGA dataset

Variable	Lower-grade glioma				Glioblastoma
	Univariate	Multivariate			Univariate	Multivariate
	P value	HR	95% CI	P value	P value	HR	95% CI	P value
Gender	0.783				0.355
Age at diagnosis	< 0.001	1.023	0.992–1.054	0.143	0.569
ADAR3 expression	< 0.001	0.419	0.289–0.608	< 0.001	0.035	0.804	0.556–1.163	0.247
MGMT promoter methylation	0.225				0.010	0.551	0.342–0.886	0.014
IDH1/2 mutation status	< 0.001	0.595	0.290–1.221	0.157	0.089
Radiotherapy	0.056				< 0.001	0.447	0.273–0.733	0.001
Chemotherapy	0.002	1.397	0.705–2.770	0.338	< 0.001	0.441	0.271–0.717	< 0.001

P value < 0.05 was considered statistically significant

CI, confidence interval; HR, hazard ratio; IDH1/2, isocitrate dehydrogenase 1/2; MGMT, O6-methylguanine-DNA methyltransferase