Figure 1.

CTR1 immunohistochemistry staining of 90 neuroblastoma patient samples. Liver and kidney represent physiological basal and elevated CTR1 expressing tissues. Graph shows that 82% of patient tumors have elevated CTR1 expression compared to liver (positive pixel counting >10,000 pixel/μm²) (A); Pictures are representative of different CTR1 expression levels: (B) Liver (Positive Control, basal expression <10,000 pixel/μm²); (C) Kidney (Positive Control, elevated expression >10,000 pixel/μm²); (D) Neuroblastoma tissue showing CTR1 basal expression (BL <10,000 pixel/μm²); (E) Neuroblastoma tissue showing moderately elevated CTR1 expression (+, 10,000-25,000 pixel/μm²); (F) Neuroblastoma tissue showing intermediate elevated CTR1 expression (++, 25,000-40,000 pixel/μm²). (G) Neuroblastoma tissue showing strongly elevated CTR1 expression (+++, >40,000 pixel/μm²). Scale bar 200 μm.