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. 2018 Nov 9;8(20):5645–5659. doi: 10.7150/thno.29840

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Dextran-Catechin effect in neuroblastoma xenograft model. Dextran-Catechin decreases tumor growth (A); it improves animal survival (B) without affecting the overall animal weight gain (C). Immunohistochemistry of tumors confirmed downregulation of CTR1 in all the tumors from mice treated with Dextran-Catechin compared to the control group (D); this is evident in the representative pictures of CTR1 staining in a tumor of a control mouse injected with saline (E); and a mouse injected with Dextran-Catechin (F). Data obtained from n=5 animals per group, deviation calculated as SEM (*: p < 0.05; **: p < 0.01).