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. 2018 Nov 5;8(20):5519–5528. doi: 10.7150/thno.27674

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The percentage of circulating regulatory T cells is increased after ASC injection in the knee. Representative dot plots to identify CD127^lowCD25⁺ cells (left), and CD25⁺FOXP3⁺ cells (right) within the CD4⁺ cell population. Gated CD4⁺ cells are in blue, and gated CD127^lowCD25⁺ cells in red. (B) Frequencies of Treg cells (CD127^lowCD25⁺ FOXP3⁺) within the CD4⁺ population at day 0 (D0, circles), day 7 (D7, squares), 1 month (M1, triangles) and 3 months (M3, inverted triangles) after injection of different amounts of ASCs (red = 2x10⁶ cells, green= 10x10⁶ cells, blue 50x10⁶ cells) in individual patients with severe OA. The percentage of Treg cells in age- and sex-matched healthy controls (CTRL) are represented in grey; *p<0.05 and **p<0.01.